Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM-Reference-Cited by-同舟云学术

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xu Cong¹²^ORCID,Wang Yanxing¹^ORCID,Liu Caixuan¹²^ORCID,Zhang Chao³^ORCID,Han Wenyu¹²^ORCID,Hong Xiaoyu¹²,Wang Yifan¹²,Hong Qin¹²,Wang Shutian¹²,Zhao Qiaoyu¹²,Wang Yalei³^ORCID,Yang Yong³,Chen Kaijian¹²,Zheng Wei¹²,Kong Liangliang⁴,Wang Fangfang⁴,Zuo Qinyu¹,Huang Zhong³^ORCID,Cong Yao¹⁵^ORCID

Affiliation:

1. State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.

2. University of Chinese Academy of Sciences, Beijing 100049, China.

3. CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

4. The National Facility for Protein Science in Shanghai (NFPS), Shanghai 201210, China.

5. Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 201210, China.

Abstract

Structure of SARS-CoV-2 spike in complex with ACE2 reveals the mechanism of ACE2 induced spike conformational transitions.

Funder

Chinese Academy of Sciences

National Basic Research Program of China

Ministry of Science and Technology of China

CAS-Shanghai Science Research Center

CAS Pilot Strategic Science and Technology Projects B

CAS Major Science and Technology Infrastructure Open Research Projects

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2

2. Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

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4. Coronavirus membrane fusion mechanism offers a potential target for antiviral development

5. The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

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