The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

Author:

Muriuki John Muthii1ORCID,Mentzer Alexander J.2ORCID,Band Gavin2ORCID,Gilchrist James J.23ORCID,Carstensen Tommy4ORCID,Lule Swaib A.56,Goheen Morgan M.78ORCID,Joof Fatou7,Kimita Wandia1ORCID,Mogire Reagan1ORCID,Cutland Clare L.9ORCID,Diarra Amidou10,Rautanen Anna2,Pomilla Cristina4ORCID,Gurdasani Deepti4ORCID,Rockett Kirk2ORCID,Mturi Neema1ORCID,Ndungu Francis M.1ORCID,Scott J. Anthony G.16,Sirima Sodiomon B.10ORCID,Morovat Alireza11ORCID,Prentice Andrew M.7ORCID,Madhi Shabir A.9,Webb Emily L.6ORCID,Elliott Alison M.56ORCID,Bejon Philip112,Sandhu Manjinder S.4,Hill Adrian V. S.213ORCID,Kwiatkowski Dominic P.24ORCID,Williams Thomas N.11214,Cerami Carla7ORCID,Atkinson Sarah H.1312ORCID

Affiliation:

1. Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme, Kilifi, Kenya.

2. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

3. Department of Paediatrics, University of Oxford, Oxford, UK.

4. Wellcome Sanger Institute, Hinxton, Cambridge, UK.

5. Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

6. London School of Hygiene and Tropical Medicine, London, UK.

7. Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.

8. University of North Carolina School of Medicine, CB 7435, Chapel Hill, North Carolina USA.

9. Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

10. Centre de Recherche Action en Sante (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso.

11. Department of Clinical Biochemistry, Oxford University Hospitals, Oxford, UK.

12. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

13. Centre for Clinical Vaccinology and Tropical Medicine and the Jenner Institute Laboratories, University of Oxford, Oxford, UK.

14. Department of Medicine, Imperial College, London, UK.

Abstract

The FPN Q248H mutation protects children from anemia, hemolysis, and iron deficiency, but not malaria or bacterial infection.

Funder

National Institute of Child Health and Human Development

Bill and Melinda Gates Foundation

Wellcome Trust

Wellcome

Medical Research Council

Department for International Development, UK Government

New Partnership for Africa’s Development

National Institute for Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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