Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition-Reference-Cited by-同舟云学术

Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition

Published:2021-11-12 Issue:46 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cascio Sandra¹²^ORCID,Chandler Chelsea¹²,Zhang Linan³,Sinno Sarah¹²,Gao Bingsi¹²,Onkar Sayali⁴⁵^ORCID,Bruno Tullia C.⁴⁵⁶^ORCID,Vignali Dario A. A.⁴⁵⁶^ORCID,Mahdi Haider¹²,Osmanbeyoglu Hatice U.³⁷,Vlad Anda M.¹²^ORCID,Coffman Lan G.¹²⁸^ORCID,Buckanovich Ronald J.¹²⁸^ORCID

Affiliation:

1. Magee-Womens Research Institute, Pittsburgh, PA 15213, USA.

2. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.

3. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213 USA.

4. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.

5. Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.

6. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.

7. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

8. Division of Hematology/Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.

Abstract

HHi reverses the CA-MSC driven tumor immune cell exclusion restoring the response to ICI.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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