Indigenous people from Amazon show genetic signatures of pathogen-driven selection-Reference-Cited by-同舟云学术

Indigenous people from Amazon show genetic signatures of pathogen-driven selection

Published:2023-03-10 Issue:10 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Couto-Silva Cainã M.¹^ORCID,Nunes Kelly¹^ORCID,Venturini Gabriela²³^ORCID,Araújo Castro e Silva Marcos¹⁴^ORCID,Pereira Lygia V.¹^ORCID,Comas David⁴^ORCID,Pereira Alexandre²³^ORCID,Hünemeier Tábita¹⁵^ORCID

Affiliation:

1. Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, 05508090, Brazil.

2. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

3. Laboratório de Genética e Cardiologia Molecular, Instituto do Coração, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

4. Institut de Biologia Evolutiva, Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Barcelona 08003, Spain.

5. Institut de Biologia Evolutiva (CSIC/Universitat Pompeu Fabra), Barcelona 08003, Spain.

Abstract

Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. This study investigates the possible footprints of genetic adaptation to the Amazon rainforest environment by analyzing the genomic data of 19 native populations. The results based on genomic and functional analysis showed an intense signal of natural selection in a set of genes related to Trypanosoma cruzi infection, which is the pathogen responsible for Chagas disease, a neglected tropical parasitic disease native to the Americas that is currently spreading worldwide.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.abo0234

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