Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer-Reference-Cited by-全球学者库

Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

Published:2021-04-09 Issue:15 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Park Su H.¹^ORCID,Fong Ka-wing¹,Kim Jung¹²^ORCID,Wang Fang¹,Lu Xiaodong¹^ORCID,Lee Yongik¹,Brea Lourdes T.¹^ORCID,Wadosky Kristine³,Guo Chunming⁴,Abdulkadir Sarki A.⁵⁶⁷,Crispino John D.¹⁶⁸⁹,Fang Deyu⁶¹⁰,Ntziachristos Panagiotis⁶⁷⁸,Liu Xin¹¹^ORCID,Li Xue⁴^ORCID,Wan Yong⁶¹²,Goodrich David W.³^ORCID,Zhao Jonathan C.¹⁶,Yu Jindan¹⁶⁷⁸^ORCID

Affiliation:

1. Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

2. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

3. Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

4. Department of Urology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.

5. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

6. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.

7. Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

8. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

9. Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Hospital, Memphis, TN, USA.

10. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

11. Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

12. Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA.

Abstract

FOXA1 is a nonhistone substrate of EZH2, promoting cell growth and sensitizing some prostate cancer to enzymatic EZH2 inhibitors.

Funder

American Cancer Society

NIH Office of the Director

Welch Foundation research grant

DOD Prostate Cancer Research Program

Prostate Cancer Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference66 articles.

1. Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

2. Androgen Receptor-Independent Function of FoxA1 in Prostate Cancer Metastasis

3. Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

4. Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program

5. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

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