Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Author:

Heino Sarika1ORCID,Fang Shentong12ORCID,Lähde Marianne1,Högström Jenny1ORCID,Nassiri Sina3,Campbell Andrew45ORCID,Flanagan Dustin45ORCID,Raven Alexander45ORCID,Hodder Michael45,Nasreddin Nadia6ORCID,Xue Hai-Hui7ORCID,Delorenzi Mauro389ORCID,Leedham Simon6,Petrova Tatiana V.89ORCID,Sansom Owen45ORCID,Alitalo Kari1ORCID

Affiliation:

1. Translational Cancer Medicine Program (CAN-PRO), iCAN Digital Precision Cancer Medicine Flagship and Wihuri Research Institute, Faculty of Medicine, HiLIFE-Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

2. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, P.R. China.

3. Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

4. Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.

5. Institute of Cancer Sciences, Garscube Estate, Glasgow G61 1QH, UK.

6. Intestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

7. Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110, USA.

8. Department of Oncology, University of Lausanne and CHUV, Epalinges, Switzerland.

9. Ludwig Institute for Cancer Research Lausanne, Epalinges, Switzerland.

Abstract

Lef1 is induced in intestinal adenomas, in which it restricts ectopic crypt formation and tumor growth.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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