Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36–inflammatory monocyte axis

Author:

Guo He-Zhou12ORCID,Guo Zi-Hua1ORCID,Yu Shan-He1ORCID,Niu Li-Ting1ORCID,Qiang Wan-Ting1ORCID,Huang Meng-Meng1ORCID,Tian Yuan-Yuan3,Chen Juan1,Yang Hui1,Weng Xiang-Qin1,Zhang Yi3ORCID,Zhang Wu1,Hu Shao-Yan4ORCID,Shi Jun2ORCID,Zhu Jiang15ORCID

Affiliation:

1. Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Collaborative Innovation Center of Hematology, Ruijin Hospital affiliated with Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.

2. Department of Hematology, Shanghai Ninth People’s Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200011, China.

3. Fels Institute, Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

4. Department of Hematology and Oncology, Children’s Hospital of Soochow University, No 92, Zhongnan Street, Suzhou 215025, China.

5. School of Life Sciences and Biotechnology, Shanghai Jiao-Tong University, Shanghai 200025, China.

Abstract

A stimulated proinflammatory feature of leukemic progenitors facilitates their survival and immune evasion after chemotherapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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