Commensal epitopes drive differentiation of colonic T regs

Author:

Kuczma Michal P.1ORCID,Szurek Edyta A.1ORCID,Cebula Anna1ORCID,Chassaing Benoit12345ORCID,Jung Yu-Jin1ORCID,Kang Sang-Moo1ORCID,Fox James G.67ORCID,Stecher Bärbel89ORCID,Ignatowicz Leszek1ORCID

Affiliation:

1. Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.

2. Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.

3. Neuroscience Institute, Georgia State University, Atlanta, GA, USA.

4. INSERM U1016, Team “Mucosal microbiota in chronic inflammatory diseases”, Paris, France.

5. Université de Paris, Paris, France.

6. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

7. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.

8. Max-von-Pettenkofer Institute, LMU Munich, Pettenkoferstr. 9a, Munich, Germany.

9. German Center for Infection Research (DZIF), partner site LMU Munich, Munich, Germany.

Abstract

Colonic commensal-derived antigens support expansion and differentiation of immunosupressive CD4 T cells.

Funder

Georgia State University

German Research Foundation

German Center for Infection Research

NIH NIAID

NIH National Cancer Institute

NIH National Institute of Environmental Health Sciences

Center for Gastrointestinal Microbiome Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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