Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair-Reference-Cited by-全球学者库

Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair

Published:2021-06-04 Issue:23 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Biferali Beatrice¹²^ORCID,Bianconi Valeria¹²^ORCID,Perez Daniel Fernandez³,Kronawitter Sophie Pöhle⁴^ORCID,Marullo Fabrizia¹²,Maggio Roberta⁵^ORCID,Santini Tiziana²⁶^ORCID,Polverino Federica¹,Biagioni Stefano²^ORCID,Summa Vincenzo⁷^ORCID,Toniatti Carlo⁷,Pasini Diego³⁸^ORCID,Stricker Sigmar⁴^ORCID,Di Fabio Romano⁷⁹,Chiacchiera Fulvio¹⁰^ORCID,Peruzzi Giovanna⁶^ORCID,Mozzetta Chiara¹^ORCID

Affiliation:

1. Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy c/o Department of Biology and Biotechnology “C. Darwin,” Sapienza University, 00185 Rome, Italy.

2. Department of Biology and Biotechnology “C. Darwin,” Sapienza University, 00185 Rome, Italy.

3. Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.

4. Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.

5. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

6. Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy.

7. IRBM Science Park, Via Pontina Km 30.600, 00070 Pomezia, Italy.

8. Department of Health Sciences, University of Milan, Via A. di Rudini 8, 20142 Milan, Italy.

9. Promidis, Via Olgettina 60, 20132 Milano, Italy.

10. Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

Abstract

A druggable mechanism is found to reprogram fibro-adipogenic progenitors toward myogenesis and to improve muscle repair.

Funder

European Research Council

Associazione Italiana per la Ricerca sul Cancro

Italina Ministry of University and Research

Association francaise contre les myopathies

CNCCS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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