A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding-Reference-Cited by-同舟云学术

A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding

Published:2020-06-26 Issue:26 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Terekhov Stanislav S.¹²^ORCID,Mokrushina Yuliana A.¹²^ORCID,Nazarov Anton S.¹^ORCID,Zlobin Alexander¹³^ORCID,Zalevsky Arthur¹³⁴^ORCID,Bourenkov Gleb⁵^ORCID,Golovin Andrey¹³⁴^ORCID,Belogurov Alexey¹,Osterman Ilya A.²⁶,Kulikova Alexandra A.⁷^ORCID,Mitkevich Vladimir A.⁷^ORCID,Lou Hua Jane⁸,Turk Benjamin E.⁸,Wilmanns Matthias⁵,Smirnov Ivan V.¹²^ORCID,Altman Sidney⁹¹⁰^ORCID,Gabibov Alexander G.¹²¹¹^ORCID

Affiliation:

1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.

2. Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.

3. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.

4. Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Moscow, Russia.

5. European Molecular Biology Laboratory, Hamburg, Germany.

6. Skolkovo Institute of Science and Technology, Skolkovo, Russia.

7. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

8. Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

9. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.

10. Arizona State University, Tempe, AZ, USA.

11. Department of Life Sciences, Higher School of Economics, Moscow, Russia.

Abstract

The substrate-driven closure determines an outstanding efficacy of antibiotic inactivation in a new kinase subfamily.

Funder

National Institutes of Health

Russian Foundation for Basic Research

Russian Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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