Critical role of spectrin in hearing development and deafness

Author:

Liu Yan1ORCID,Qi Jieyu123ORCID,Chen Xin4ORCID,Tang Mingliang23ORCID,Chu Cenfeng14ORCID,Zhu Weijie123ORCID,Li Hui1,Tian Cuiping1,Yang Guang5,Zhong Chao6ORCID,Zhang Ying7,Ni Guangjian89ORCID,He Shuijin4ORCID,Chai Renjie23101112ORCID,Zhong Guisheng13413ORCID

Affiliation:

1. iHuman Institute, ShanghaiTech University, Shanghai, China.

2. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.

3. Co-innovation Center of Neuroregeneration, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.

4. School of Life Science and Technology, ShanghaiTech University, Shanghai, China.

5. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.

6. School of Physical Science and Technology, ShanghaiTech University, Shanghai, China.

7. Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, 5850 College Street, Halifax, Canada.

8. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.

9. Laboratory of Neural Engineering and Rehabilitation, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, China.

10. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.

11. Research Institute of Otolaryngology, No.321 Zhongshan Road, Nanjing, China.

12. Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, 100069, China.

13. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Abstract

Super-resolution fluorescence imaging reveals a previously unknown novel structure of spectrin in inner ear hair cells.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Thousand Youth Talents Plan of China

the Strategic Priority Research Program of the Chinese Academy of Science

Boehringer Ingelheim Pharma GmbH

Yingdong Huo Education Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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