Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells

Author:

Dong Jiantong12ORCID,Jan Yu Jen13ORCID,Cheng Ju1,Zhang Ryan Y.1ORCID,Meng Meng14ORCID,Smalley Matthew1,Chen Pin-Jung13,Tang Xinghong1ORCID,Tseng Patrick1ORCID,Bao Lirong1ORCID,Huang Tzu-Yang5,Zhou Dongjing6,Liu Yupin6,Chai Xiaoshu6,Zhang Haibo6,Zhou Anqi1ORCID,Agopian Vatche G.7,Posadas Edwin M.3ORCID,Shyue Jing-Jong8ORCID,Jonas Steven J.9ORCID,Weiss Paul S.10ORCID,Li Mengyuan2ORCID,Zheng Guangjuan6ORCID,Yu Hsiao-hua5ORCID,Zhao Meiping2ORCID,Tseng Hsian-Rong1ORCID,Zhu Yazhen1ORCID

Affiliation:

1. California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Beijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

3. Urologic Oncology Program and Uro-Oncology Research Laboratories, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

4. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.

5. Smart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan.

6. Department of Pathology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China.

7. Department of Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.

8. Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.

9. Department of Pediatrics, David Geffen School of Medicine, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Children’s Discovery and Innovation Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

10. California NanoSystems Institute, Departments of Chemistry and Biochemistry and Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Dong et al . report gene rearrangement detection in circulating tumor cells by using covalent chemistry on nanosubstrates.

Funder

National Institutes of Health

China Scholarship Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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