A single-cell multi-omic atlas spanning the adult rhesus macaque brain-Reference-Cited by-同舟云学术

A single-cell multi-omic atlas spanning the adult rhesus macaque brain

Published:2023-10-13 Issue:41 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chiou Kenneth L.¹²^ORCID,Huang Xingfan³⁴^ORCID,Bohlen Martin O.⁵^ORCID,Tremblay Sébastien⁶,DeCasien Alex R.⁷,O’Day Diana R.⁸^ORCID,Spurrell Cailyn H.⁸⁹^ORCID,Gogate Aishwarya A.⁸⁹^ORCID,Zintel Trisha M.¹²,Andrews Madeline G.¹⁰^ORCID,Martínez Melween I.¹¹^ORCID,Starita Lea M.³⁸^ORCID,Montague Michael J.⁶^ORCID,Platt Michael L.⁶¹²¹³^ORCID,Shendure Jay³⁸¹⁴¹⁵^ORCID,Snyder-Mackler Noah¹²¹⁶¹⁷^ORCID,

Affiliation:

1. Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.

2. School of Life Sciences, Arizona State University, Tempe, AZ, USA.

3. Department of Genome Sciences, University of Washington, Seattle, WA, USA.

4. Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.

5. Department of Biomedical Engineering, Duke University, Durham, NC, USA.

6. Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.

7. Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, MD, USA.

8. Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.

9. Seattle Children's Research Institute, Seattle, WA, USA.

10. School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.

11. Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.

12. Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA.

13. Marketing Department, University of Pennsylvania, Philadelphia, PA, USA.

14. Howard Hughes Medical Institute, Seattle, WA, USA.

15. Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA.

16. School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA.

17. ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA.

Abstract

Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. Together, we profiled 2.58 M transcriptomes and 1.59 M epigenomes from single nuclei sampled from 30 regions across the adult brain. Cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions. We also identified 1.19 M candidate regulatory elements, many previously unidentified, allowing us to explore the landscape of cis-regulatory grammar and neurological disease risk in a cell type–specific manner. Altogether, this multi-omic atlas provides an open resource for investigating the evolution of the human brain and identifying novel targets for disease interventions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adh1914

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