The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

Author:

Keihani S.1ORCID,Kluever V.1ORCID,Mandad S.12,Bansal V.34ORCID,Rahman R.3,Fritsch E.1ORCID,Gomes L. Caldi56ORCID,Gärtner A.7ORCID,Kügler S.5,Urlaub H.28,Wren J. D.9ORCID,Bonn S.34ORCID,Rizzoli S. O.16,Fornasiero E. F.16ORCID

Affiliation:

1. Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Excellence Cluster Multiscale Bioimaging, 37073 Göttingen, Germany.

2. Department of Clinical Chemistry, University Medical Center Göttingen, 37077 Göttingen, Germany.

3. Institute of Medical Systems Biology, Center for Molecular Neurobiology (ZMNH), UKE, 20246 Hamburg, Germany.

4. German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.

5. Department of Neurology, University Medical Center Göttingen, 37073 Göttingen, Germany.

6. Center for Biostructural Imaging of Neurodegeneration (BIN), 37075 Göttingen, Germany.

7. VIB Center for the Biology of Disease and Center for Human Genetics, KU Leuven, Leuven, Belgium.

8. Bioanalytical Mass Spectrometry Group, Max Planck Institute of Biophysical Chemistry, 37077 Göttingen, Germany.

9. Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Abstract

NeuroLNC , a previously unknown long ncRNA, regulates neuronal activity by interacting with the neurodegeneration protein TDP-43.

Funder

European Molecular Biology Organization

European Research Council

Human Frontier Science Program

Deutsche Forschungsgemeinschaft

German Research Foundation Collaborative Research Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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