Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target-Reference-Cited by-全球学者库

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Published:2020-08-28 Issue:35 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yuan Shuofeng¹²³⁴^ORCID,Chu Hin¹²³⁴^ORCID,Huang Jingjing²^ORCID,Zhao Xiaoyu²^ORCID,Ye Zi-Wei²^ORCID,Lai Pok-Man²^ORCID,Wen Lei²^ORCID,Cai Jian-Piao²^ORCID,Mo Yufei⁵^ORCID,Cao Jianli²^ORCID,Liang Ronghui²^ORCID,Poon Vincent Kwok-Man²^ORCID,Sze Kong-Hung¹²³^ORCID,Zhou Jie¹²³⁴^ORCID,To Kelvin Kai-Wang¹²³⁴⁵^ORCID,Chen Zhiwei¹²³⁶^ORCID,Chen Honglin¹²³⁴^ORCID,Jin Dong-Yan⁷^ORCID,Chan Jasper Fuk-Woo¹²³⁴⁵^ORCID,Yuen Kwok-Yung¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

2. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

3. Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

4. Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

5. Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China.

6. AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

7. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Abstract

Host AP2M1 protein is exploited by diverse pathogenic viruses via their YxxØ protein motif during viral replication cycle.

Funder

Research Grants Council, University Grants Committee, Hong Kong

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Evolutionary conflicts between viruses and restriction factors shape immunity

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3. Zika Virus