Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal

Author:

Adeluyi Adewale1ORCID,Guerin Lindsey1,Fisher Miranda L.12ORCID,Galloway Ashley3ORCID,Cole Robert D.34,Chan Sherine S. L.56,Wyatt Michael D.1ORCID,Davis Shannon W.7ORCID,Freeman Linnea R.8ORCID,Ortinski Pavel I.34,Turner Jill R.12ORCID

Affiliation:

1. Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA.

2. Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, KY, USA.

3. Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, USA.

4. Department of Neuroscience, University of Kentucky School of Medicine, Lexington, KY, USA.

5. Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.

6. Neuroene Therapeutics, Mt Pleasant, SC, USA.

7. Department of Biology, Furman University, Greenville, SC, USA.

8. Department of Biological Sciences, University of South Carolina, Columbia, SC, USA.

Abstract

Nearly 80% of smokers attempting to quit fail, but research on microglia may open a new avenue for smoking cessation drugs.

Funder

National Institutes of Health

PhRMA Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference67 articles.

1. Tobacco smoking: The leading cause of preventable disease worldwide;Samet J. M.;Thorac. Surg. Clin.,2013

2. The detox strategy in smoking comprising nutraceutical formulas of non-hydrolyzed carnosine or carcinine used to protect human health;Babizhayev M. A.;Hum. Exp. Toxicol.,2013

3. Treatment of nicotine addiction: Present therapeutic options and pipeline developments;Polosa R.;Trends Pharmacol. Sci.,2011

4. World Health Organization WHO Global Report: Mortality Attributable to Tobacco. Geneva Switzerland (2012); http://apps.who.int/iris/bitstream/10665/44815/1/9789241564434_eng.pdf.

5. Varenicline: An α4β2 nicotinic receptor partial agonist for smoking cessation;Coe J. W.;J. Med. Chem.,2005

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