DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation-Reference-Cited by-全球学者库

DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation

Published:2020-03-27 Issue:13 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ma Ruining¹^ORCID,Ma Lina²^ORCID,Weng Weiji¹^ORCID,Wang Yingping¹^ORCID,Liu Huiqing¹^ORCID,Guo Rongjun¹,Gao Yingwei¹,Tu Jun¹,Xu Tian-Le³^ORCID,Cheng Jinke¹^ORCID,Zhu Michael X.⁴^ORCID,Zhou Aiwu²^ORCID,Li Yong¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

4. Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Abstract

Our work uncovers a novel SUMOylation-dependent regulation of DUSP6 stability and its activity, which regulates Drp1 function.

Funder

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

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2. Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo

3. RALA and RALBP1 regulate mitochondrial fission at mitosis