Massive clonal expansion of polycytotoxic skin and blood CD8 + T cells in patients with toxic epidermal necrolysis-Reference-Cited by-同舟云学术

Massive clonal expansion of polycytotoxic skin and blood CD8 + T cells in patients with toxic epidermal necrolysis

Published:2021-03-19 Issue:12 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Villani Axel Patrice¹²^ORCID,Rozieres Aurore¹^ORCID,Bensaid Benoît²,Eriksson Klara Kristin³^ORCID,Mosnier Amandine¹^ORCID,Albert Floriane¹,Mutez Virginie¹,Brassard Océane¹,Baysal Tugba¹,Tardieu Mathilde¹,Allatif Omran¹^ORCID,Fusil Floriane¹,Andrieu Thibault¹⁴^ORCID,Jullien Denis¹²^ORCID,Dubois Valérie⁵^ORCID,Giannoli Catherine⁵,Gruffat Henri¹^ORCID,Pallardy Marc⁶,Cosset François-Loïc¹,Nosbaum Audrey¹⁷,Kanagawa Osami¹^ORCID,Maryanski Janet L.⁸,Yerly Daniel³⁹^ORCID,Nicolas Jean-François¹⁷^ORCID,Vocanson Marc¹

Affiliation:

1. Centre International de Recherche en Infectiologie (CIRI); INSERM, U1111; Université de Lyon 1; Ecole Normale Supérieure de Lyon; and CNRS, UMR 5308, Lyon, France.

2. Drug Allergy Reference Center, Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Dermatologie, Lyon, France.

3. Department of Rheumatology, Immunology and Allergology, Drug Allergy Research Laboratory, University Hospital of Bern, 3010 Bern, Switzerland.

4. SFR Biosciences Gerland, US8, UMS3444, Lyon, France.

5. Etablissement Français du Sang (EFS), Décines, France.

6. INSERM, UMR 996, Châtenay-Mallabry, France.

7. Département d’Allergologie et d’immunologie Clinique, Hôpital Lyon Sud, Pierre-Bénite, France.

8. Unité de Thérapie Cellulaire et Génique (UTCG), Centre Hospitalier Universitaire de Nice, 06101 Nice, France.

9. ADR-AC GmbH, Holligenstrasse 91, 3008 Bern, Switzerland.

Abstract

This study highlights the key role of polycytotoxic CD8 + T cells in the severity of toxic epidermal necrolysis.

Funder

French National Research Agency

French Society of Dermatology

French Society of Allergology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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