Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses-Reference-Cited by-同舟云学术

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

Published:2019-12-06 Issue:12 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Blumberg L. J.¹^ORCID,Humphries J. E.²,Jones S. D.³,Pearce L. B.²,Holgate R.⁴,Hearn A.⁴^ORCID,Cheung J.⁵,Mahmood A.⁵^ORCID,Del Tito B.²^ORCID,Graydon J. S.¹,Stolz L. E.¹,Bitonti A.¹^ORCID,Purohit S.³,de Graaf D.¹^ORCID,Kacena K.⁶^ORCID,Andersen J. T.⁷⁸,Christianson G. J.⁹,Roopenian D. C.⁹,Hubbard J. J.¹⁰¹¹,Gandhi A. K.¹⁰,Lasseter K.¹²^ORCID,Pyzik M.¹⁰^ORCID,Blumberg R. S.¹⁰^ORCID

Affiliation:

1. Syntimmune Inc., Boston, MA 02116, USA.

2. Biologics Consulting, Alexandria, VA 22314, USA.

3. BioProcess Technology Consultants, Woburn, MA 01801, USA.

4. Abzena, Babraham, Cambridge, CB22 3AT, UK.

5. New York Structural Biology Center, New York, NY 10027, USA.

6. BioBridges, Wellesley, MA 02481, USA.

7. Department of Immunology and Centre for Immune Regulation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo 0424, Norway.

8. Department of Pharmacology, Institute of Clinical Medicine, University of Oslo, Oslo 0424, Norway.

9. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

10. Department of Medicine, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

11. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA.

12. Clinical Pharmacology of Miami, Miami, FL 33014, USA.

Abstract

Therapeutic blockade of FcRn in humans decreases IgG and IgG immune complex levels with the attendant immunologic implications.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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