A microneedle platform for buccal macromolecule delivery

Author:

Caffarel-Salvador Ester12ORCID,Kim Soyoung2ORCID,Soares Vance2ORCID,Tian Ryan Yu2,Stern Sarah R.2ORCID,Minahan Daniel2ORCID,Yona Raissa2ORCID,Lu Xiaoya2,Zakaria Fauziah R.2ORCID,Collins Joy23ORCID,Wainer Jacob2,Wong Jessica2,McManus Rebecca2ORCID,Tamang Siddartha2,McDonnell Shane2,Ishida Keiko2ORCID,Hayward Alison234ORCID,Liu Xiewen25,Hubálek František6ORCID,Fels Johannes6ORCID,Vegge Andreas6,Frederiksen Morten Revsgaard6ORCID,Rahbek Ulrik6ORCID,Yoshitake Tadayuki7,Fujimoto James7ORCID,Roxhed Niclas28ORCID,Langer Robert129ORCID,Traverso Giovanni239ORCID

Affiliation:

1. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, UK.

6. Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Måløv, Denmark.

7. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. School of Electrical Engineering and Computer Science, Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden.

9. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Microneedles with high drug-loaded tips allow fast and painless delivery of biologics into the buccal mucosa.

Funder

National Institutes of Health

Novo Nordisk

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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