Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Author:

Dominy Stephen S.1ORCID,Lynch Casey1,Ermini Florian1ORCID,Benedyk Malgorzata23,Marczyk Agata2,Konradi Andrei1,Nguyen Mai1ORCID,Haditsch Ursula1ORCID,Raha Debasish1,Griffin Christina1,Holsinger Leslie J.1,Arastu-Kapur Shirin1,Kaba Samer1,Lee Alexander1,Ryder Mark I.4ORCID,Potempa Barbara5ORCID,Mydel Piotr26,Hellvard Annelie36,Adamowicz Karina2,Hasturk Hatice78,Walker Glenn D.9ORCID,Reynolds Eric C.9ORCID,Faull Richard L. M.10,Curtis Maurice A.1112,Dragunow Mike1113,Potempa Jan25ORCID

Affiliation:

1. Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.

2. Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

3. Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.

4. Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.

5. Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.

6. Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.

7. The Forsyth Institute, Cambridge, MA, USA.

8. Harvard University School of Dental Medicine, Boston, MA, USA.

9. Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.

10. Department of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

11. Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

12. Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

13. Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Abstract

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.

Funder

Cortexyme, Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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