High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines-Reference-Cited by-同舟云学术

High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines

Published:2022-11-11 Issue:45 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Rinchai Darawan¹²^ORCID,Deola Sara¹^ORCID,Zoppoli Gabriele³⁴,Kabeer Basirudeen Syed Ahamed¹,Taleb Sara⁵^ORCID,Pavlovski Igor¹^ORCID,Maacha Selma¹,Gentilcore Giusy¹^ORCID,Toufiq Mohammed¹^ORCID,Mathew Lisa¹^ORCID,Liu Li¹,Vempalli Fazulur Rehaman¹^ORCID,Mubarak Ghada¹,Lorenz Stephan¹,Sivieri Irene⁴⁶⁷,Cirmena Gabriella³^ORCID,Dentone Chiara³,Cuccarolo Paola⁴,Giacobbe Daniele Roberto³⁶^ORCID,Baldi Federico⁶,Garbarino Alberto⁴,Cigolini Benedetta⁴^ORCID,Cremonesi Paolo⁸,Bedognetti Michele⁹^ORCID,Ballestrero Alberto³⁶,Bassetti Matteo³⁶^ORCID,Hejblum Boris P.¹⁰^ORCID,Augustine Tracy¹^ORCID,Van Panhuys Nicholas¹^ORCID,Thiebaut Rodolphe¹⁰^ORCID,Branco Ricardo¹^ORCID,Chew Tracey¹¹^ORCID,Shojaei Maryam¹²¹³¹⁴,Short Kirsty¹⁵¹⁶^ORCID,Feng Carl G.¹⁷¹⁸^ORCID,Zughaier Susu M.¹⁹^ORCID,De Maria Andrea³⁶,Tang Benjamin¹³^ORCID,Ait Hssain Ali²⁰²¹^ORCID,Bedognetti Davide¹⁴^ORCID,Grivel Jean-Charles¹^ORCID,Chaussabel Damien¹²²^ORCID,

Affiliation:

1. Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar.

2. Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA.

3. IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

4. Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.

5. Division of Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.

6. Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.

7. Department of Experimental and Clinical Medicine, School of Internal Medicine, University of Florence, Florence, Italy.

8. Emergency Department, E.O. Ospedali Galliera, Genova, Italy.

9. Azienda Sanitaria Locale 3 Genovese, Genova, Liguria, Italy.

10. Univ. Bordeaux, Department of Public Health, Inserm U1219 Bordeaux Population Health Research Centre, Inria SISTM, F-33000 Bordeaux, France.

11. Sydney Informatic Hub, The University of Sydney, Sydney, New South Wales, Australia.

12. Nepean Clinical School, The University of Sydney, Sydney, New South Wales, Australia.

13. Westmead Institute for Medical Research, Westmead, New South Wales, Australia.

14. Department of Medicine, Sydney Medical School, Nepean Hospital, The University of Sydney, Sydney, New South Wales, Australia.

15. The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Brisbane, Queensland, Australia.

16. Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.

17. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

18. Tuberculosis Research Program, Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia.

19. College of Medicine, QU Health, Qatar University, PO Box 2713, Doha, Qatar.

20. Medical Intensive Care Unit, Hamad General Hospital, PO BOX 3050, Doha, Qatar.

21. Weill Cornell Medical College, Doha, Qatar.

22. Computational Sciences Department, The Jackson Laboratory, Farmington, CT, USA.

Abstract

Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference68 articles.

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