Modified cyclodextrins as broad-spectrum antivirals

Author:

Jones Samuel T.12ORCID,Cagno Valeria13ORCID,Janeček Matej1,Ortiz Daniel4,Gasilova Natalia4,Piret Jocelyne5,Gasbarri Matteo1ORCID,Constant David A.6ORCID,Han Yanxiao7,Vuković Lela8ORCID,Král Petr79,Kaiser Laurent10ORCID,Huang Song11,Constant Samuel11ORCID,Kirkegaard Karla6ORCID,Boivin Guy5,Stellacci Francesco112ORCID,Tapparel Caroline3ORCID

Affiliation:

1. Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.

2. Department of Materials, University of Manchester, Manchester M13 9PL, UK.

3. Department of Microbiology and Molecular Medicine, University of Geneva, Geneva 1211, Switzerland.

4. Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

5. CHU of Québec-Laval University, Québec City, Québec, Canada.

6. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Department of Chemistry, University of Illinois, Chicago, IL 60607, USA.

8. Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX 79966, USA.

9. Department of Physics, and Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL 60612, USA.

10. Division of Infectious diseases, University Hospitals of Geneva, Geneva, Switzerland.

11. Epithelix Sàrl, Geneva, Switzerland.

12. Department of Bionengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.

Abstract

Sulfonated cyclodextrins show nontoxic, broad-spectrum virucidal activity in vitro, ex vivo, and in vivo.

Funder

National Institute of Allergy and Infectious Diseases

Canadian Institutes of Health Research

Swiss National Science Foundation

Fondation Leenaards

Firmenich Foundation

Dame Kathleen Ollerenshaw Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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