Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration

Author:

Yao Bin123ORCID,Wang Rui4,Wang Yihui5,Zhang Yijie1ORCID,Hu Tian126ORCID,Song Wei2,Li Zhao1,Huang Sha1ORCID,Fu Xiaobing12ORCID

Affiliation:

1. Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing 100853, P. R. China.

2. Key Laboratory of Tissue Repair and Regeneration of PLA and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China.

3. The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.

4. Chinese PLA 306 Hospital, Beijing 100000, P.R. China.

5. Handan People’s Hospital, Hebei 056000, P.R. China.

6. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

Abstract

3D-bioprinted microenvironment directs MSC differentiation and promotes SG regeneration.

Funder

National Natural Science Foundation of China

National Key Research Development Plan

Military Logistics Research Key Project

Fostering Funds of Chinese PLA General Hospital for National Distinguished Young Scholar Science Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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