Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets-Reference-Cited by-同舟云学术

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Published:2021-01-06 Issue:2 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Neff Ryan A.¹²³⁴^ORCID,Wang Minghui¹²³^ORCID,Vatansever Sezen¹²³,Guo Lei¹²³^ORCID,Ming Chen¹²³^ORCID,Wang Qian¹²³,Wang Erming¹²³,Horgusluoglu-Moloch Emrin¹²³,Song Won-min¹²³^ORCID,Li Aiqun¹³⁵⁶⁷^ORCID,Castranio Emilie L.⁸^ORCID,TCW Julia⁵⁹^ORCID,Ho Lap¹²³^ORCID,Goate Alison¹³⁵⁶⁹^ORCID,Fossati Valentina¹⁰^ORCID,Noggle Scott¹⁰^ORCID,Gandy Sam⁷¹¹⁸,Ehrlich Michelle E.¹¹¹²,Katsel Pavel⁷¹³^ORCID,Schadt Eric¹³^ORCID,Cai Dongming¹¹¹⁴^ORCID,Brennand Kristen J.¹³⁵⁶^ORCID,Haroutunian Vahram⁵⁶⁸¹⁵¹³^ORCID,Zhang Bin¹²³¹⁶^ORCID

Affiliation:

1. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

2. Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

3. Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

4. Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

6. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

7. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

8. Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

9. Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

10. New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.

11. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York NY 10029, USA.

12. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

13. Psychiatry, JJ Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.

14. Neurology, JJ Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.

15. Mental Illness Research, Education and Clinical Centers, JJ Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.

16. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Abstract

Three major molecular subtypes of Alzheimer’s disease are identified, cross-validated, and characterized across 1543 individuals.

Funder

National Institutes of Health

Illinois Department of Public Health

Translational Genomics Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

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2. The critical need for defining preclinical biomarkers in Alzheimer's disease

3. The Cellular Phase of Alzheimer’s Disease

4. Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

5. Mild Cognitive Impairment and Asymptomatic Alzheimer Disease Subjects

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