Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs

Author:

Alves Vinicius M.12ORCID,Hwang Duhyeong3ORCID,Muratov Eugene14ORCID,Sokolsky-Papkov Marina3,Varlamova Ekaterina2,Vinod Natasha35ORCID,Lim Chaemin3,Andrade Carolina H.2,Tropsha Alexander1ORCID,Kabanov Alexander36

Affiliation:

1. Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

2. Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goiás, Goiania, GO 74605-170, Brazil.

3. Center for Nanotechnology in Drug Delivery, Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

4. Department of Pharmaceutical Sciences, Federal University of Paraíba, Joao Pessoa, PB 58059, Brazil.

5. UNC/NC State Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA.

6. Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119992, Russia.

Abstract

Computer-assisted strategy for drug delivery leads to discovery of polymeric micelle formulations for poorly soluble drugs.

Funder

National Institutes of Health

CNPq

Carolina Center for Cancer Nanotechnology Excellence

NC TraCS Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

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3. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers;Slowing I. I.;Adv. Drug Deliv. Rev.,2008

4. Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities;Kabanov A. V.;Angew. Chem. Int. Ed.,2009

5. Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery;Kabanov A. V.;J. Control. Release,2002

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