DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension

Author:

Yan Yi1ORCID,He Yang-Yang2,Jiang Xin3,Wang Yong4,Chen Ji-Wang5,Zhao Jun-Han2,Ye Jue2,Lian Tian-Yu3,Zhang Xu6,Zhang Ru-Jiao7,Lu Dan3,Guo Shan-Shan8,Xu Xi-Qi3,Sun Kai3,Li Su-Qi2,Zhang Lian-Feng6,Zhang Xue9,Zhang Shu-Yang3ORCID,Jing Zhi-Cheng123ORCID

Affiliation:

1. Department of Cardiopulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

2. State Key Laboratory of Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

3. State Key Laboratory of Complex, Severe, and Rare Diseases, and Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

4. Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

5. Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

6. Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China.

7. Hebei University Health Science Center, Hebei, China.

8. Biochemistry, Pharmaceutical College, Henan University, Henan, China.

9. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Abstract

DNA methyltransferase 3B is identified as a protective target against pulmonary vascular remodeling.

Funder

National Natural Science Foundation of China

Beijing Natural Science Foundation

CAMS Innovation Fund for Medical Sciences

13th Five-Year Plan - Precision Medicine - Key Research and Development Program - Clinical Cohort of Rare Disease

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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