Sequence variants affecting voice pitch in humans-Reference-Cited by-同舟云学术

Sequence variants affecting voice pitch in humans

Published:2023-06-09 Issue:23 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Gisladottir Rosa S.¹²^ORCID,Helgason Agnar¹³^ORCID,Halldorsson Bjarni V.¹⁴^ORCID,Helgason Hannes¹,Borsky Michal⁴,Chien Yu-Ren⁴^ORCID,Gudnason Jon⁴^ORCID,Gudjonsson Sigurjon A.¹^ORCID,Moisik Scott⁵^ORCID,Dediu Dan⁶⁷⁸^ORCID,Thorleifsson Gudmar¹^ORCID,Tragante Vinicius¹^ORCID,Bustamante Mariana¹,Jonsdottir Gudrun A.¹,Stefansdottir Lilja¹,Rutsdottir Gudrun¹^ORCID,Magnusson Sigurdur H.¹,Hardarson Marteinn¹^ORCID,Ferkingstad Egil¹^ORCID,Halldorsson Gisli H.¹⁹^ORCID,Rognvaldsson Solvi¹^ORCID,Skuladottir Astros¹^ORCID,Ivarsdottir Erna V.¹,Norddahl Gudmundur¹^ORCID,Thorgeirsson Gudmundur¹¹⁰,Jonsdottir Ingileif¹¹⁰^ORCID,Ulfarsson Magnus O.¹⁹^ORCID,Holm Hilma¹^ORCID,Stefansson Hreinn¹^ORCID,Thorsteinsdottir Unnur¹¹⁰^ORCID,Gudbjartsson Daniel F.¹⁹^ORCID,Sulem Patrick¹^ORCID,Stefansson Kari¹¹⁰^ORCID

Affiliation:

1. deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

2. Department of Icelandic and Comparative Cultural Studies, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland.

3. Department of Anthropology, University of Iceland, Saemundargata 10, 102 Reykjavik, Iceland.

4. Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.

5. Division of Linguistics and Multilingual Studies, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.

6. Department of Catalan Philology and General Linguistics, University of Barcelona, Gran Via 585, Barcelona 08007, Spain.

7. University of Barcelona Institute for Complex Systems (UBICS), Martí Franquès 1, Barcelona 08028, Spain.

8. Catalan Institute for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain.

9. School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.

10. Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Abstract

The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.abq2969

Reference99 articles.

1. M. C. Corballis From Hand to Mouth: The Origins of Language (Princeton Univ. Press 2002).

2. W. T. Fitch The Evolution of Language (Cambridge Univ. Press 2010).

3. A forkhead-domain gene is mutated in a severe speech and language disorder

4. Genetic pathways involved in human speech disorders

5. Genetics of the voice

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Toward an evolutionary account of the changes in the human pitch vocal system;Frontiers in Psychology;2023-10-19

2. Is song processing distinct and special in the auditory cortex?;Nature Reviews Neuroscience;2023-10-02

3. Have a high-pitched voice? It might be in your genes;Nature;2023-06-09

4. Vocal Pitch: Formidability;Encyclopedia of Sexual Psychology and Behavior;2023