Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin-Reference-Cited by-同舟云学术

Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin

Published:2024-01-26 Issue:4 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jiang Wei I.¹^ORCID,De Belly Henry¹²,Wang Bingying¹,Wong Andrew¹,Kim Minseo¹^ORCID,Oh Fiona¹,DeGeorge Jason¹^ORCID,Huang Xinya³,Guang Shouhong³,Weiner Orion D.¹²^ORCID,Ma Dengke K.¹⁴⁵^ORCID

Affiliation:

1. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

2. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.

3. The USTC RNA Institute, Division of Life Sciences and Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei, Anhui, China.

4. Department of Physiology, University of California, San Francisco, San Francisco, CA, USA.

5. Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.

Abstract

Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates tsp-1 , a gene encoding the conserved transmembrane tetraspanin in C. elegans . TSP-1 forms prominent multimers and stable web-like structures critical for membrane barrier functions in adults and during aging. Increased TSP-1 abundance persists even after transient early-life heat stress. Such regulation requires CBP-1, a histone acetyltransferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adj3880

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