A splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccine

Author:

Zhai Yuewen1ORCID,He Xiaorong1ORCID,Li Ying1,Han Ran1,Ma Yuying1,Gao Peng2,Qian Zhiyu3,Gu Yueqing1ORCID,Li Siwen1ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Screening, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing 211198, Jiangsu Province, China.

2. Chia Tai Tianqing Pharmaceutical Group Co. Ltd., No.1099, Fuying Road, Jiangning District, Jiangsu Province, Nanjing, China.

3. Department of Biomedical Engineering, School of Automation, Nanjing University of Aeronautics and Astronautics, 29th JiangJun Street, Jiangsu Province, Nanjing 211106, China.

Abstract

Dilated erythrocyte membrane specifically transfer iPSC to spleen for effective tumor prevention.

Funder

National Natural Science Foundation of China

Government of Jiangsu Province

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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