Chemical conversion of human epidermal stem cells into intestinal goblet cells for modeling mucus-microbe interaction and therapy

Author:

Zhao Andong12ORCID,Qin Hua13ORCID,Sun Mengli13,Tang Mao2,Mei Jinyu2,Ma Kui1,Fu Xiaobing134ORCID

Affiliation:

1. Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical College, 28 Fu Xing Road, Haidian District, Beijing 100853, China.

2. Tianjin Medical University, Tianjin 300070, China.

3. PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing 100048, China.

4. Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, Beijing 100048, China.

Abstract

Induced goblet cells are useful for studying the interaction of intestinal mucus layer and the gut microbiota.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

National Key Research and Development Program of China Stem Cell and Translational Research

CAMS Innovation Fund for Medical Sciences

the Military Medical Research and Development Projects

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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