Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis-Reference-Cited by-同舟云学术

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Published:2020-07-10 Issue:28 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Habermann Arun C.¹^ORCID,Gutierrez Austin J.²,Bui Linh T.²^ORCID,Yahn Stephanie L.²^ORCID,Winters Nichelle I.¹,Calvi Carla L.¹,Peter Lance²,Chung Mei-I²,Taylor Chase J.¹^ORCID,Jetter Christopher³^ORCID,Raju Latha⁴^ORCID,Roberson Jamie⁴,Ding Guixiao¹,Wood Lori⁵,Sucre Jennifer M. S.³,Richmond Bradley W.¹⁶,Serezani Ana P.¹,McDonnell Wyatt J.⁷^ORCID,Mallal Simon B.⁷⁸⁹,Bacchetta Matthew J.¹⁰,Loyd James E.¹,Shaver Ciara M.¹^ORCID,Ware Lorraine B.¹⁷,Bremner Ross⁵^ORCID,Walia Rajat⁵^ORCID,Blackwell Timothy S.¹⁶¹¹,Banovich Nicholas E.²^ORCID,Kropski Jonathan A.¹⁶¹¹^ORCID

Affiliation:

1. Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

2. Translational Genomics Research Institute, Phoenix, AZ, USA.

3. Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

4. Vanderbilt Center for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA.

5. Department of Thoracic Disease and Transplantation, Norton Thoracic Institute, Phoenix, AZ, USA.

6. Department of Veterans Affairs Medical Center, Nashville, TN, USA.

7. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

8. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

9. Institute for Immunology and Infectious Diseases, Murdoch University, Discovery Way, Murdoch, Western Australia 6150, Australia.

10. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

11. Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.

Abstract

Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.

Funder

National Heart, Lung, and Blood Institute

Doris Duke Charitable Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference68 articles.

1. Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

2. Idiopathic Pulmonary Fibrosis

3. An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias

4. Heterozygosity for a Surfactant Protein C Gene Mutation Associated with Usual Interstitial Pneumonitis and Cellular Nonspecific Interstitial Pneumonitis in One Kindred

5. Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

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