A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood

Author:

Ng Dianna L.12ORCID,Granados Andrea C.23ORCID,Santos Yale A.23,Servellita Venice23ORCID,Goldgof Gregory M.2ORCID,Meydan Cem456ORCID,Sotomayor-Gonzalez Alicia23ORCID,Levine Andrew G.2,Balcerek Joanna2,Han Lucy M.1,Akagi Naomi1ORCID,Truong Kent1,Neumann Neil M.1ORCID,Nguyen David N.7ORCID,Bapat Sagar P.278,Cheng Jing910ORCID,Martin Claudia Sanchez-San23,Federman Scot23ORCID,Foox Jonathan456,Gopez Allan23,Li Tony11,Chan Ray2,Chu Cynthia S.2,Wabl Chiara A.23,Gliwa Amelia S.23,Reyes Kevin23,Pan Chao-Yang12,Guevara Hugo12,Wadford Debra12ORCID,Miller Steve23ORCID,Mason Christopher E.451314ORCID,Chiu Charles Y.238ORCID

Affiliation:

1. Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

2. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

3. UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

4. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

5. The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

6. WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

7. Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.

8. Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.

9. Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, San Francisco, CA, USA.

10. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

11. Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, CA, USA.

12. Viral and Rickettsial Disease Laboratory, California Department of Health, Richmond, CA, USA.

13. New York Genome Center, New York, NY, USA.

14. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Abstract

SARS-CoV-2 infection elicits a distinct host response in nasal swabs and blood that can be used to diagnose COVID-19.

Funder

National Institutes of Health

Abbott Laboratories

Pershing Square Sohn Cancer Research Alliance

Citadel Foundation

WorldQuant Foundation

Charles and Helen Schwab Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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