Characterizing dedifferentiation of thyroid cancer by integrated analysis

Author:

Luo Han1ORCID,Xia Xuyang2ORCID,Kim Gyeong Dae3ORCID,Liu Yang1ORCID,Xue Zhinan2,Zhang Lingyun1,Shu Yang24ORCID,Yang Tian5ORCID,Chen Yan2,Zhang Shouyue2ORCID,Chen Haining4ORCID,Zhang Weihan4ORCID,Li Ruicen6,Tang Huairong6,Dong Birong7,Fu Xianghui2ORCID,Cheng Wei2,Zhang Wei8,Yang Li2ORCID,Peng Yong2ORCID,Dai Lunzhi2ORCID,Hu Hongbo2ORCID,Jiang Yong5,Gong Changyang2,Hu Yiguo12ORCID,Zhu Jingqiang1ORCID,Li Zhihui1,Caulin Carlos9ORCID,Wei Tao1ORCID,Park Jihwan3ORCID,Xu Heng210ORCID

Affiliation:

1. Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.

3. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.

4. Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

5. Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

6. Health Promotion Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

7. National Clinical Research Center for Geriatrics, Chengdu, Sichuan, China.

8. Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

9. Department of Otolaryngology—Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.

10. Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Abstract

Clinical staining and targeting CREB3L1 facilitates precise stratification and a potential treatment strategy for thyroid cancer.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

National Key Research and Development Program of China Stem Cell and Translational Research

Samsung Science and Technology Foundation

Sichuan Science and Technology Program

Post-Doctor Research Project, West China Hospital, Sichuan University

1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University

International Cooperation Project of Chengdu Municipal Science and Technology Bureau

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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