Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

Author:

Kaduri Maya1ORCID,Sela Mor1,Kagan Shaked1ORCID,Poley Maria1ORCID,Abumanhal-Masarweh Hanan12,Mora-Raimundo Patricia1ORCID,Ouro Alberto345ORCID,Dahan Nitsan6ORCID,Hershkovitz Dov7ORCID,Shklover Jeny1ORCID,Shainsky-Roitman Janna1,Buganim Yosef4ORCID,Schroeder Avi1ORCID

Affiliation:

1. The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion—Israel Institute of Technology, Haifa 32000, Israel.

2. The Norman Seiden Multidisciplinary Program for Nanoscience and Nanotechnology, Technion—Israel Institute of Technology, Haifa 32000, Israel.

3. Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Spain.

4. Department of Developmental Biology and Cancer Research and The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

5. Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.

6. Life Sciences and Engineering Infrastructure Center, Lorry I. Lokey Interdisciplinary Center, Technion—Israel Institute of Technology, Haifa 3200003, Israel.

7. Pathology Institute, Sourasky Medical Center, Tel Aviv, Israel.

Abstract

Targeting neurons in breast cancer with anesthetic nanoparticles inhibits nerve-cancer stimulation and tumor progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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