Swarming self-adhesive microgels enabled aneurysm on-demand embolization in physiological blood flow-Reference-Cited by-同舟云学术

Swarming self-adhesive microgels enabled aneurysm on-demand embolization in physiological blood flow

Published:2023-05-12 Issue:19 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jin Dongdong¹²^ORCID,Wang Qinglong²,Chan Kai Fung³⁴^ORCID,Xia Neng²^ORCID,Yang Haojin²,Wang Qianqian²⁵^ORCID,Yu Simon Chun Ho⁶⁷^ORCID,Zhang Li²³⁴⁸^ORCID

Affiliation:

1. School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518071, Guangdong, China.

2. Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

3. Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

4. Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

5. Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing 211000, China.

6. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

7. Vascular and Interventional Radiology Foundation Clinical Science Centre, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

8. T-Stone Robotics Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong 999077, China.

Abstract

The recent rise of swarming microrobotics offers great promise in the revolution of minimally invasive embolization procedure for treating aneurysm. However, targeted embolization treatment of aneurysm using microrobots has significant challenges in the delivery capability and filling controllability. Here, we develop an interventional catheterization-integrated swarming microrobotic platform for aneurysm on-demand embolization in physiological blood flow. A pH-responsive self-healing hydrogel doped with magnetic and imaging agents is developed as the embolic microgels, which enables long-term self-adhesion under biological condition in a controllable manner. The embolization strategy is initiated by catheter-assisted deployment of swarming microgels, followed by the application of external magnetic field for targeted aggregation of microrobots into aneurysm sac under the real-time guidance of ultrasound and fluoroscopy imaging. Mild acidic stimulus is applied to trigger the welding of microgels with satisfactory bio-/hemocompatibility and physical stability and realize complete embolization. Our work presents a promising connection between the design and control of microrobotic swarms toward practical applications in dynamic environments.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adf9278

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