Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway-Reference-Cited by-同舟云学术

Mycobacterial EST12 activates a RACK1–NLRP3–gasdermin D pyroptosis–IL-1β immune pathway

Published:2020-10-23 Issue:43 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Qu Zilu¹^ORCID,Zhou Jin²^ORCID,Zhou Yidan³,Xie Yan¹^ORCID,Jiang Yanjing²^ORCID,Wu Jian¹,Luo Zuoqin²^ORCID,Liu Guanghui¹^ORCID,Yin Lei²^ORCID,Zhang Xiao-Lian¹⁴^ORCID

Affiliation:

1. Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology of School of Basic Medical Sciences and Department of Allergy of Zhongnan Hospital, Wuhan University, Wuhan 430071, China.

2. State Key Laboratory of Virology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Wuhan University, Wuhan 430077, China.

3. Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

4. State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430071, China.

Abstract

EST12/Rv1579c activates a RACK1–NLRP3–GSDMD pyroptosis–IL-1β immune pathway to increase mycobacterial clearance.

Funder

National Natural Science Foundation of China

National Outstanding Youth Foundation of China

The Fundamental Research Funds for the Central Universities of China

National Key R & D Program of China

National Grand Program on Key Infectious Disease

the Major Projects of Technological Innovation of Hubei Province

Natural Science Foundation Project of Hubei Province

Medical Science Advancement Program (Basical Medical Sciences) of Wuhan University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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2. M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages

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4. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

5. The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

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