Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli

Author:

Bethke Jonathan H.1ORCID,Davidovich Adam2ORCID,Cheng Li345,Lopatkin Allison J.2ORCID,Song Wenchen34,Thaden Joshua T.6,Fowler Vance G.16ORCID,Xiao Minfeng34ORCID,You Lingchong127ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708, USA.

2. Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

3. BGI-Shenzhen, Shenzhen 518083, China.

4. China National Genebank, BGI-Shenzhen, Shenzhen 518120, China.

5. School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.

6. Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

7. Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA.

Abstract

Integrating genomics with growth-based phenotyping reveals divergent roles of antibiotics and incompatibility in plasmid mobility.

Funder

National Science Foundation

National Institutes of Health

David and Lucile Packard Foundation

Army Research Office

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. J. O’Neill Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations (Review on Antimicrobial Resistance 2014) pp. 1–16 .

2. M. Barlow in Horizontal Gene Transfer: Genomes in Flux B. G. Maria J. P. Gogarten L. Olendzenski Eds. (Humana Press 2009) vol. 532 pp. 397–411.

3. Sampling the Antibiotic Resistome

4. Inhibiting conjugation as a tool in the fight against antibiotic resistance

5. Exposing plasmids as the Achilles’ heel of drug-resistant bacteria

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