Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study-Reference-Cited by-同舟云学术

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Published:2023-01-13 Issue:2 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lapatto Helena A. K.¹^ORCID,Kuusela Minna²^ORCID,Heikkinen Aino³^ORCID,Muniandy Maheswary¹^ORCID,van der Kolk Birgitta W.¹^ORCID,Gopalakrishnan Swetha⁴^ORCID,Pöllänen Noora²^ORCID,Sandvik Martin⁴^ORCID,Schmidt Mark S.⁵^ORCID,Heinonen Sini¹^ORCID,Saari Sina¹^ORCID,Kuula Juho⁶⁷⁸^ORCID,Hakkarainen Antti⁶^ORCID,Tampio Janne⁹^ORCID,Saarinen Tuure¹¹⁰^ORCID,Taskinen Marja-Riitta²^ORCID,Lundbom Nina⁶^ORCID,Groop Per-Henrik²¹¹¹²¹³^ORCID,Tiirola Marja¹⁴^ORCID,Katajisto Pekka⁴¹⁵^ORCID,Lehtonen Marko⁹^ORCID,Brenner Charles¹⁶^ORCID,Kaprio Jaakko²^ORCID,Pekkala Satu¹⁷^ORCID,Ollikainen Miina²¹⁸^ORCID,Pietiläinen Kirsi H.¹¹⁹^ORCID,Pirinen Eija²²⁰^ORCID

Affiliation:

1. Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.

2. Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland.

3. Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

4. Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

5. Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

6. Department of Radiology, Medical Imaging Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

7. Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.

8. Population Health Unit, Finnish Institute for Health and Welfare, Oulu, Finland.

9. School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

10. Abdominal Center, Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland.

11. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.

12. Abdominal Center, Nephrology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

13. Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia.

14. Department of Environmental and Biological Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.

15. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

16. Department of Diabetes and Cancer Metabolism, City of Hope National Medical Center, Duarte, CA 91010, USA.

17. Faculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.

18. Minerva Foundation Institute for Medical Research, Helsinki, Finland.

19. Abdominal Center, Healthy Weight Hub, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

20. Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, FIN-90220 Oulu, Finland.

Abstract

Nicotinamide adenine dinucleotide (NAD + ) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans. Twenty body mass index (BMI)–discordant monozygotic twin pairs were supplemented with an escalating dose of NR (250 to 1000 mg/day) for 5 months. NR improved systemic NAD + metabolism, muscle mitochondrial number, myoblast differentiation, and gut microbiota composition in both cotwins. NR also showed a capacity to modulate epigenetic control of gene expression in muscle and adipose tissue in both cotwins. However, NR did not ameliorate adiposity or metabolic health. Overall, our results suggest that NR acts as a potent modifier of NAD + metabolism, muscle mitochondrial biogenesis and stem cell function, gut microbiota, and DNA methylation in humans irrespective of BMI.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.add5163

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