Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration-Reference-Cited by-全球学者库

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Published:2019-02 Issue:2 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kim Jaeryung¹²³^ORCID,Park Jang Ryul⁴⁵^ORCID,Choi Jeongwoon¹²,Park Intae¹²,Hwang Yoonha⁵⁶,Bae Hosung¹²^ORCID,Kim Yongjoo⁴⁵^ORCID,Choi WooJhon⁵,Yang Jee Myung²^ORCID,Han Sangyeul¹^ORCID,Chung Tae-Young³,Kim Pilhan⁵⁶^ORCID,Kubota Yoshiaki⁷^ORCID,Augustin Hellmut G.⁸⁹^ORCID,Oh Wang-Yuhl⁴⁵,Koh Gou Young¹²^ORCID

Affiliation:

1. Center for Vascular Research, Institute for Basic Science (IBS), Daejeon 34141, Republic of Korea.

2. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

3. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

4. Department of Mechanical Engineering, KAIST, Daejeon 34141, Republic of Korea.

5. KI for Health Science and Technology (KIHST), KAIST, Daejeon 34141, Republic of Korea.

6. Graduate School of Nanoscience and Technology, KAIST, Daejeon 34141, Republic of Korea.

7. The Laboratory of Vascular Biology, School of Medicine, Keio University, Tokyo 160-8582, Japan.

8. European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.

9. Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg 69121, Germany.

Abstract

Angpt-Tie2 is essential for choriocapillary maintenance, and Tie2 activation could be a therapeutic avenue for fundamental treatment of NV-AMD.

Funder

Institute for Basic Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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