Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1-Reference-Cited by-同舟云学术

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1

Published:2020-07-03 Issue:27 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Barra Jasmine¹²³⁴⁵^ORCID,Gaidosh Gabriel S.⁶,Blumenthal Ezra⁶^ORCID,Beckedorff Felipe⁶^ORCID,Tayari Mina M.⁶^ORCID,Kirstein Nina⁶^ORCID,Karakach Tobias K.⁷⁸^ORCID,Jensen Torben Heick⁹^ORCID,Impens Francis³⁴¹⁰^ORCID,Gevaert Kris³⁴^ORCID,Leucci Eleonora⁵^ORCID,Shiekhattar Ramin⁶^ORCID,Marine Jean-Christophe¹²^ORCID

Affiliation:

1. Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.

2. Laboratory for Molecular Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.

3. VIB Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium.

4. Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium.

5. Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, Leuven, Belgium.

6. Sylvester Comprehensive Cancer Center, Department of Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami, FL 33136, USA.

7. Bioinformatics Core Laboratory, Children’s Hospital Research Institute of Manitoba (CHRIM), Winnipeg, Manitoba, Canada.

8. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

9. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

10. VIB Proteomics Core, 9000 Ghent, Belgium.

Abstract

Integrator is a key regulator of NEAT1 isoform switching and, thereby, paraspeckles biogenesis and chemosensitivity.

Funder

Fondation contre le Cancer

Emmanuel van der Schueren

Funds André Vander Stricht, Emile Carpentier and Van Damme-King Baudouin foundation

NIH-R01

NIH-DP1

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

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5. Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II

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