Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine-Reference-Cited by-同舟云学术

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Published:2021-09-03 Issue:36 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zhou Yitian¹^ORCID,Arribas Gabriel Herras¹^ORCID,Turku Ainoleena¹²^ORCID,Jürgenson Tuuli³,Mkrtchian Souren¹^ORCID,Krebs Kristi³⁴^ORCID,Wang Yi⁵^ORCID,Svobodova Barbora⁶^ORCID,Milani Lili³^ORCID,Schulte Gunnar¹^ORCID,Korabecny Jan⁶^ORCID,Gastaldello Stefano¹^ORCID,Lauschke Volker M.¹⁷^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

2. Orion Pharma R&D, P.O. Box 65 (Orionintie 1), FI-02101 Espoo, Finland.

3. Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.

4. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

5. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China.

6. Biomedical Research Centre, University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic.

7. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

Abstract

Rare genetic variants in human drug targets affect drug efficacy and can guide personalized drug selection and drug development.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.abi6856

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