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Rapid approach to complex boronic acids

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Neochoritis Constantinos G.¹^ORCID,Shaabani Shabnam¹^ORCID,Ahmadianmoghaddam Maryam¹,Zarganes-Tzitzikas Tryfon¹,Gao Li¹^ORCID,Novotná Michaela¹,Mitríková Tatiana¹^ORCID,Romero Atilio Reyes¹^ORCID,Irianti Marina Ika¹^ORCID,Xu Ruixue¹,Olechno Joe²,Ellson Richard²,Helan Victoria³^ORCID,Kossenjans Michael³^ORCID,Groves Matthew R.¹^ORCID,Dömling Alexander¹^ORCID

Affiliation:

1. Pharmacy Department, Drug Design group, University of Groningen, Deusinglaan 1, 9700 AV Groningen, Netherlands.

2. Labcyte Inc., 170 Rose Orchard Way, San Jose, CA 95134, USA.

3. Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Mölndal, Gothenburg SE-43183, Sweden.

Abstract

Nanoliter acoustic dispensing technology is an efficient way to synthesize large, diverse, and complex libraries of boronic acids.

Funder

Hartstichting

National Institute of Health

Qatar National Research Foundation

European Lead Factory

Accelerated Early stage drug dIScovery

COFUND ALERT

KWF Kankerbestrijding grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. The versatility of boron in biological target engagement;Diaz D. B.;Nat. Chem.,2017

2. A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides;Miyaura N.;Tetrahedron Lett.,1979

3. Palladium-catalyzed cross-coupling reactions of organoboron compounds;Miyaura N.;Chem. Rev.,1995

4. The boronic acid mannich reaction: A new method for the synthesis of geometrically pure allylamines;Petasis N. A.;Tetrahedron Lett.,1993

5. New N- and O-arylations with phenylboronic acids and cupric acetate;Chan D. M. T.;Tetrahedron Lett.,1998

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