In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape-Reference-Cited by-同舟云学术

In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape

Published:2023-06-16 Issue:24 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Luppi Andrea I.¹²³⁴⁵^ORCID,Hansen Justine Y.⁵^ORCID,Adapa Ram¹^ORCID,Carhart-Harris Robin L.⁶,Roseman Leor⁷^ORCID,Timmermann Christopher⁷^ORCID,Golkowski Daniel⁸,Ranft Andreas⁹^ORCID,Ilg Rüdiger⁸¹⁰,Jordan Denis¹¹¹²,Bonhomme Vincent¹³¹⁴^ORCID,Vanhaudenhuyse Audrey¹³^ORCID,Demertzi Athena¹⁵^ORCID,Jaquet Oceane¹³^ORCID,Bahri Mohamed Ali¹⁵^ORCID,Alnagger Naji L. N.¹³^ORCID,Cardone Paolo¹³^ORCID,Peattie Alexander R. D.¹²^ORCID,Manktelow Anne E.¹^ORCID,de Araujo Draulio B.¹⁶^ORCID,Sensi Stefano L.¹⁷¹⁸^ORCID,Owen Adrian M.¹⁹^ORCID,Naci Lorina²⁰^ORCID,Menon David K.¹²¹^ORCID,Misic Bratislav⁵^ORCID,Stamatakis Emmanuel A.¹²^ORCID

Affiliation:

1. Division of Anaesthesia, University of Cambridge, Cambridge, UK.

2. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

3. Leverhulme Centre for the Future of Intelligence, University of Cambridge, Cambridge, UK.

4. The Alan Turing Institute, London, UK.

5. McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

6. Psychedelics Division - Neuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

7. Center for Psychedelic Research, Department of Brain Sciences, Imperial College London, London, UK.

8. Department of Neurology, Klinikum rechts der Isar, Technical University Munich, München, Germany.

9. School of Medicine, Department of Anesthesiology and Intensive Care, Technical University of Munich, Munich, Germany.

10. Department of Neurology, Asklepios Clinic, Bad Tölz, Germany.

11. Department of Anaesthesiology and Intensive Care Medicine, Klinikum rechts der Isar, Technical University Munich, München, Germany.

12. University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.

13. Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium.

14. Anesthesia and Perioperative Neuroscience Laboratory, GIGA-Consciousness Thematic Unit, GIGA-Research, Liege University, Liege, Belgium.

15. GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liege, Liege, Belgium.

16. Brain Institute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

17. Department of Neuroscience and Imaging and Clinical Science, Center for Advanced Studies and Technology, Institute for Advanced Biomedical Technologies, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.

18. Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA, USA.

19. Department of Psychology and Department of Physiology and Pharmacology, Western Institute for Neuroscience (WIN), Western University, London, ON, Canada.

20. Trinity College Institute of Neuroscience, School of Psychology, Trinity College Dublin, Dublin, Ireland.

21. Wolfon Brain Imaging Centre, University of Cambridge, Cambridge, UK.

Abstract

To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters obtained from positron emission tomography, and the regional changes in functional magnetic resonance imaging connectivity induced by 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, and methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs’ effects on brain function and multiple neurotransmitter systems. The effects of both anesthetics and psychedelics on brain function are organized along hierarchical gradients of brain structure and function. Last, we show that regional co-susceptibility to pharmacological interventions recapitulates co-susceptibility to disorder-induced structural alterations. Collectively, these results highlight rich statistical patterns relating molecular chemoarchitecture and drug-induced reorganization of the brain’s functional architecture.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adf8332

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