Pooled CRISPR screening identifies m 6 A as a positive regulator of macrophage activation

Author:

Tong Jiyu123,Wang Xuefei12ORCID,Liu Yongbo12ORCID,Ren Xingxing4ORCID,Wang Anmin4,Chen Zonggui5ORCID,Yao Jiameng1,Mao Kaiqiong12,Liu Tingting67,Meng Fei-Long67ORCID,Pan Wen4,Zou Qiang1,Liu Jun8,Zhou Yu5ORCID,Xia Qiang9,Flavell Richard A.1011,Zhu Shu4,Li Hua-Bing129

Affiliation:

1. Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Shanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Department of Pediatrics and Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, China.

4. Hefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.

5. Institute for Advanced Studies, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.

6. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.

7. University of Chinese Academy of Sciences, Beijing 100049, China.

8. School of Life Sciences, Peking University, Beijing 100871, China.

9. Department of Liver Surgery and State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

10. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8055, USA.

11. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520-8055, USA.

Abstract

CRISPR screening identifies RNA m 6 A modification as negative regulator of TLR signaling pathway for proper innate immune response.

Funder

Howard Hughes Medical Institute

National Natural Science Foundation of China

Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

National Key Research and Development Program of China Stem Cell and Translational Research

Strategic Priority Research Program of the Chinese Academy of Sciences

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 98 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3