Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

Author:

Zhang Ke1ORCID,Miorin Lisa23ORCID,Makio Tadashi4,Dehghan Ishmael56,Gao Shengyan1,Xie Yihu7,Zhong Hualin8,Esparza Matthew1ORCID,Kehrer Thomas29ORCID,Kumar Anil4ORCID,Hobman Tom C.4,Ptak Christopher4,Gao Boning10,Minna John D.1011ORCID,Chen Zhijian56ORCID,García-Sastre Adolfo231213ORCID,Ren Yi7,Wozniak Richard W.4,Fontoura Beatriz M.A.1ORCID

Affiliation:

1. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

4. Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.

5. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

6. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37235, USA.

8. Department of Biological Sciences, Hunter College, New York, NY 10065, USA.

9. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

10. Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

11. Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

12. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

13. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

SARS-CoV-2 Nsp1 protein binds the mRNA export receptor NXF1-NXT1 to inhibit nuclear export of mRNAs and promote infection.

Funder

National Cancer Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Canadian Institutes of Health Research

Cancer Prevention and Research Institute of Texas

Defense Sciences Office, DARPA

JBP Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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