Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor

Author:

Wen Tianlei1ORCID,Wang Ziyu1,Chen Xiaozhe1,Ren Yue1ORCID,Lu Xuhang1ORCID,Xing Yangfei2ORCID,Lu Jing1ORCID,Chang Shenghai34ORCID,Zhang Xing34ORCID,Shen Yuequan15ORCID,Yang Xue1ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300350, China.

2. State Key Laboratory of Medical Genomics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200025, China.

3. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

4. Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou, China.

5. Synergetic Innovation Center of Chemical Science and Engineering, Tianjin 300071, China.

Abstract

Multiple structures of full-length calcium-sensing receptors reveal the mechanism of activation and allosteric modulation.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

National Key Research and Development Program of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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