Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

Author:

Yang Wei1ORCID,Warrington Nicole M.2,Taylor Sara J.2ORCID,Whitmire Paula3ORCID,Carrasco Eduardo3,Singleton Kyle W.3ORCID,Wu Ningying45,Lathia Justin D.6ORCID,Berens Michael E.7ORCID,Kim Albert H.89,Barnholtz-Sloan Jill S.10ORCID,Swanson Kristin R.35ORCID,Luo Jingqin411,Rubin Joshua B.29ORCID

Affiliation:

1. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Precision Neurotherapeutics Innovation Program, Mathematical NeuroOncology Lab, Mayo Clinic, Phoenix, AZ 85054, USA.

4. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.

5. School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85281, USA.

6. Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland OH, 44195, USA.

7. Cancer and Cell Biology Division, TGen, Phoenix, AZ 85004, USA.

8. Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

9. Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.

10. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

11. Siteman Cancer Center Biostatistics Core, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Male and female glioblastomas are biologically distinct, and improving outcomes may require sex-specific approaches to treatment.

Funder

NIH Office of the Director

James S. McDonnell Foundation

The Ben and Catherine Ivy Foundation

Children's Discovery Institute

Joshua's Great Things

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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