Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria-Reference-Cited by-同舟云学术

Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria

Published:2018-08-03 Issue:26 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Balin Samuel J.¹²^ORCID,Pellegrini Matteo³^ORCID,Klechevsky Eynav⁴^ORCID,Won Sohui T.²,Weiss David I.⁵^ORCID,Choi Aaron W.²,Hakimian Joshua²,Lu Jing³,Ochoa Maria Teresa⁶^ORCID,Bloom Barry R.⁷,Lanier Lewis L.⁸^ORCID,Stenger Steffen⁹,Modlin Robert L.¹²^ORCID

Affiliation:

1. Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

2. Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

3. Molecular Cell and Developmental Biology at UCLA, Los Angeles, CA 90095, USA.

4. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63108, USA.

5. Molecular Biology Interdepartmental Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

6. Department of Dermatology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.

7. Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

8. Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.

9. Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.

Abstract

Intracellular bacteria are killed by human antimicrobial CD8 + T cells that express NKG2C and secrete granzyme B, perforin, and granulysin.

Funder

NIH Office of the Director

Dermatology Foundation

Parker Institute for Cancer Immunotherapy

Translation Centre for the Bodies of the European Union

German Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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