NLRP3 inflammasome activation triggers gasdermin D–independent inflammation

Author:

Wang Chun1ORCID,Yang Tong12,Xiao Jianqiu1ORCID,Xu Canxin3,Alippe Yael1ORCID,Sun Kai12,Kanneganti Thirumala-Devi4ORCID,Monahan Joseph B.3ORCID,Abu-Amer Yousef56ORCID,Lieberman Judy7ORCID,Mbalaviele Gabriel1ORCID

Affiliation:

1. Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China.

3. Aclaris Therapeutics Inc., St. Louis, MO 63108, USA.

4. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

5. Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.

6. Shriners Hospital for Children, St. Louis, MO 63110, USA.

7. Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.

Abstract

Sustained stimulation of the NLRP3 inflammasome causes inflammation in the absence of GSDMD.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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